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By Bethel Solomons (Auth.)

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Streptococcal conditions probably commonest cause. D R U G S . — I o d i d e s , b r o m i d e s , s u l p h o n a m i d e s , penicillin, especially. P a t h o l o g y . — H e a v y p o l y m o r p h i n f i l t r a t e i n a n d a r o u n d t h e v e s s e l s of t h e d e r m i s , w i t h a few l y m p h o c y t e s a n d p l a s m a cells. T h e l u m e n of s o m e vessels m a y b e o b l i t e r a t e d b y s w e l l i n g of e n d o t h e l i a l cells. I n f i l t r a t e is a l s o f o u n d in s u b c u t a n e o u s f a t .

Vesicles o c c u r o n l i p s , t o n g u e , b u c c a l m u c o s a , p h a r y n x , a n d o t h e r orifices. Pseudomembranes appear, making eating and d r i n k i n g difficult a n d e v e n t r a c h e o t o m y s o m e t i m e s n e c e s s a r y . E . m u l t i f o r m e lesions u s u a l l y a p p e a r o n h a n d s a n d feet. Ocular s y m p t o m s are severe a n d m a y lead t o p a r t i a l or t o t a l blindness. I t begins with conjunctivitis. T r e a t m e n t . — P r e d n i s o l o n e a n d A C T H a r e t h e m o s t useful d r u g s .

I c h t h y o t i c lesions a r e p r e s e n t o n t h e flanks a n d axillae. T h e d w a r f s a r e of t h e L e v i - L o r a i n , o r primordial type. HEREDITARY ŒDEMA OF (Milroy's Disease) LEGS A f a m i l i a l d i s e a s e o c c u r r i n g in s e v e r a l g e n e r a t i o n s , c h a r a c t e r i z e d b y solid p e r s i s t e n t o e d e m a of t h e l o w e r l i m b s . I t a p p e a r s s h o r t l y a f t e r b i r t h , o r m a y n o t a p p e a r u n t i l p u b e r t y o r l a t e r .

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