By Esen Özkaya, Kurtuluş Didem Yazganoğlu
Adverse cutaneous drug reactions (ACDR) are one of the such a lot common occasions in sufferers receiving drug remedy. Cardiovascular (CV) medicinal drugs are a huge crew of substances with strength hazard of constructing ACDR in particular in aged as advertising of extra new medicines and their prescription proceed to extend. despite the fact that, like with such a lot different medicines the precise occurrence of cutaneous unwanted effects from CV medicinal drugs is hard to estimate because of sporadic reporting. furthermore, a competent designation of a undeniable drug because the reason for a undeniable form of response can hardly ever be made. except the well known angioedema/urticaria from ACE inhibitors, lichen planus / lichenoid response from beta adrenergic blockers and photosensitivity from thiazid diuretics, ACDR from CV medications will be noticeable in a large spectrum extending to infrequent yet life-threatening stipulations comparable to erythroderma, Stevens-Johnson syndrome, poisonous epidermal necrolysis or drug allergy syndrome. during this accomplished overview, the stated forms of ACDR to CV medicinal drugs can be mentioned in keeping with drug category and the kind of dermatologic response with particular emphasize on cross-reactions and the function of patch checking out in diagnosis.
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Extra resources for Adverse Cutaneous Drug Reactions to Cardiovascular Drugs
15 Baboon syndrome with the characteristic, bright-red erythema on the gluteal area Fig. 16 Symmetrical erythema on the groins and the upper inner surface of the thighs in a V-shaped pattern in Baboon syndrome 1 General Aspects of Adverse Cutaneous Drug Reactions Characteristic Features of Adverse Cutaneous Drug Reactions 13 Fig. 17 Symmetrical lesions on major flexural and intertriginous areas such as the axillae and antecubital fossae in SDRIFE (symmetrical drug-related intertriginous and flexural exanthema) other intertriginous/flexural fold, (4) symmetry of affected areas, and (5) absence of systemic symptoms and signs .
Nikolsky’s sign is present. There might be a chronic urticarial/eczematous preblistering prodrome in drug-induced pemphigus which may help in differentiating it from idiopathic pemphigus [4, 25]. Also, there is lack of strong positivity rates in direct immunofluorescence (DIF) in drug-induced pemphigus [4, 25]. Similar to idiopathic pemphigus, mucosal involvement is also common in drug-induced pemphigus. Characteristic Features of Adverse Cutaneous Drug Reactions 23 Fig. 36 Erosions and crusts resulting from rupture of flaccid bullae on the trunk of a patient with pemphigus vulgaris Clinical findings of drug-induced pemphigoid are usually indistinguishable from the idiopathic form showing tense, subepidermal bullae, either on an erythematous or normal skin (Fig.
Oral contraceptives and sulfonamides are common inducers. Drug-Induced Erythroderma/Exfoliative Dermatitis Erythroderma/exfoliative dermatitis is characterized by widespread confluent erythema that is often associated with desquamation, involving more than 80 % of the body surface (Figs. 57). It is a condition with a significant risk of morbidity and mortality. , maculopapular, lichenoid, eczematous, may evolve into erythroderma during their course. It usually begins within a few weeks following treatment with the causative drug.